Induction of a distinct CD8 Tnc17 subset by transforming growth factor- and interleukin-6
نویسندگان
چکیده
Cross-talk between TGFand IL-6 has been shown to direct the differentiation of CD4 cells into special IL-17-secreting cells, which are termed Th17 cells. In this study, we demonstrated that TGFand IL-6 could stimulate CD8 cells to differentiate into noncytotoxic, IL-17-producing cells in MLC. These IL17-producing CD8 cells exhibit a unique granzyme BIFNIL-10 phenotype. The mRNA level of Th2/T cytotoxic 2 (Tc2) transcription factors GATA3 and Th1/Tc1 transcription factors T-box expressed in T cell (T-bet) as well as its target H2 O-like homeobox (Hlx) is decreased in CD8 cells from TGFand IL-6-treated MLC. In addition, these CD8 cells display a marked up-regulation of retinoic acid-related orphan receptort, a key IL-17 transcription factor. These results demonstrate that the existence of an IL-17-producing CD8 subset belongs to neither the Tc1 nor the Tc2 subset and can be categorized as a T noncytotoxic 17 (Tnc17) subset. J. Leukoc. Biol. 82: 354–360; 2007.
منابع مشابه
Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6.
Cross-talk between TGF-beta and IL-6 has been shown to direct the differentiation of CD4(+) cells into special IL-17-secreting cells, which are termed Th17 cells. In this study, we demonstrated that TGF-beta and IL-6 could stimulate CD8(+) cells to differentiate into noncytotoxic, IL-17-producing cells in MLC. These IL-17-producing CD8(+) cells exhibit a unique granzyme B(-)IFN-gamma(-)IL-10(-)...
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